Evaluation of Serum Clusterin Levels in Type 2 Diabetic Men with and without Cardiovascular Disease

Authors

  • Safa S. Fayez Department of Biology, College of Sciences, University of Anbar, Ramadi, Iraq
  • Rashied. M. Rashied Department of Biology, College of Sciences, University of Anbar, Ramadi, Iraq
  • Shakir F.T. Al-Alaaraji Department of Chemistry, College of Education for Pure Sciences, University of Anbar, Ramadi, Iraq

DOI:

https://doi.org/10.24996/ijs.2020.61.5.5

Keywords:

Clusterin, Troponin-I, insulin resistance, Type 2 diabetes mellitus, CVD

Abstract

Objectives: The objective of this study was to evaluate serum levels of clusterin (CLU) in type 2 diabetics with and without cardiovascular disease and to explore possible correlations with insulin resistance and related progression of cardiovascular disease in Iraqi men.

Methods: Sixty-three T2DM patients, including forty-two with cardiovascular disease (CVD), were divided into three subgroups; twenty-one with myocardial infraction (MI), twenty-one with other CVD, and twenty-one without any cardiac complication. In addition, a group of twenty-one men served as healthy controls (HCs) for comparison purposes. The four groups were analyzed for parameters that included fasting serum glucose (FSG), lipid profile, fasting serum insulin (FSI), homeostasis model assessment of insulin resistance (HOMA-IR), cardiac Troponin-I (cTn-I),  CK-MB, and some other biochemical variables.

Results: Our results showed that the serum CLU levels were higher in T2DM with MI than  the other groups of patients, while the levels were significantly elevated in the entire T2DM group as compared to the control group. Serum levels of CLU showed significantly positive correlations with cTn-I and CK-MB (r= 0.658 p < 0.01and r = 0.575, p < 0.01 , respectively), whereas the correlation with HDL-C was negative. However, the other parameters exhibited weak correlations with serum CLU levels.

Conclusions: CLU participates in the event of cardiovascular disease and insulin resistance    in Iraqi males with T2DM and may be used as predictor for CVD development in T2DM patients.

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Published

2020-05-28

Issue

Section

Biology

How to Cite

Evaluation of Serum Clusterin Levels in Type 2 Diabetic Men with and without Cardiovascular Disease. (2020). Iraqi Journal of Science, 61(5), 978-984. https://doi.org/10.24996/ijs.2020.61.5.5
Crossref
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Russell S. A. Al-Shaabani, Shakir F. T. Alaaraj (2024)
A Correlation of Alarin with Some Anthropometric Measurements in Iraqi Type II Diabetic Patients. Medical Journal of Babylon, 21(4), 1027.
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Serum Levels of Protein Z, Laminin Subunit Alpha 2, Mixed Lineage Leukemia 4, and Plexin Domain Containing 2 in Newly Diagnosed and Metformin-Treated Type 2 Diabetes Patients. Iraqi Journal of Science, 65(10), 5357-5369.
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An Association of Galanin with some biochemical parameters in Iraqi Type II Diabetic Patients. Journal of University of Anbar for Pure Science, 17(2), 107-114.
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Evaluation of Serum Cytokeratin 20 and some Trace Elements in Type 2 Diabetic patients with and without COVID19. Egyptian Journal of Chemistry, 66(4), 101-108.
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Karim H.R. (2021-10-01)
EVALUATION OF SERUM CLUSTERIN AND ENZYME ACTIVITY OF GLUTATHIONE S-TRANSFERASE (GST) IN ACUTE MYOCARDIAL INFARCTION. Biochemical and Cellular Archives, 21(2), 4319-4325.
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