Assessment of hepatitis C viral load and genotypes by molecular determination in Iraqi patients treated with Ledipasvir/sofosbuvir (Harvoni) drug

Authors

  • Sahib A. Hussein Ministry of Health, Baghdad Health Alkarkh Directorate, Alfurat Hospital & University of Baghdad/ College of Science/ Department of Biology
  • Raghad H. Al-azzawi University of Baghdad/ College of Science/ Department of Biology
  • Duraid Qassim Alshareef Director of National center of Teaching Laboratory

DOI:

https://doi.org/10.24996/ijs.2021.62.5.5

Keywords:

Hepatitis C virus, viral load, viral genotypes

Abstract

Hepatitis C virus ( HCV) is a significant global health threat that is responsible for approximately 170 million chronic infections worldwide. A feasible research was conducted to provide more understanding of viral load, effectiveness of Harvoni drug on virus concentration, and distribution of virus genotypes in Iraqi patients. Ninety eight HCV cases were investigated in this research , including 52 untreated, with an average age ± SE of 45.26 ± 2.97 years, and 46 treated with Harvoni therapy, with an average age of 39.30 ± 3.90 years. In addition, eighty healthy persons with an average age of 29.40 ± 2.84 years were included as control. These cases were attending to the Special Nursing Home Hospital in Baghdad between December 2018 and January 2019. They were diagnosed with this disease by using a real-time PCR to concentrate the viral level and determine viral genotypes. Statistical analysis showed that high substantial variances in virus concentration between untreated and treated patients and between both groups versus apparently healthy volunteers group (p < 0.01). Furthermore, genotype 4 was shown to be higher in our sample of Iraqi hepatitis C patients in comparison with the other patterns.

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Published

2021-05-30

Issue

Section

Biology

How to Cite

Assessment of hepatitis C viral load and genotypes by molecular determination in Iraqi patients treated with Ledipasvir/sofosbuvir (Harvoni) drug. (2021). Iraqi Journal of Science, 62(5), 1431-1437. https://doi.org/10.24996/ijs.2021.62.5.5
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Single Nucleotide Polymorphism of Interleukin-28β Subunit Genes Predict Host Susceptibility to Hepatitis C virus (HCV) Infection among Iraqi Patients. Iraqi Journal of Science, 65(5), 2385-2396.
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Hepatocellular Carcinoma Prediction and early Diagnosis of Hepatitis B and C viral infection using miR-122 and miR-223 in a sample of Iraqi patients. Baghdad Science Journal, 20, 1520-1531.

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