Design and Synthesis of several new developed Sulfa Drugs and screening of  their Antimicrobial and Antifungal  Activities

Sura S. Raoof; Ahlam Marouf  Al-Azzawi

doi:10.24996/ijs.2026.67.2.4

Authors

Sura S. Raoof Department of Chemistry, College of Science, University of Baghdad, Baghdad, Iraq https://orcid.org/0000-0002-1253-7417
Ahlam Marouf Al-Azzawi Department of Pharmaceutical Chemistry, College of Pharmacy, Mustansiriyah University, Baghdad, Iraq

DOI:

https://doi.org/10.24996/ijs.2026.67.2.4

Keywords:

Sulfa Drugs, N-drug amic acid, N-drug cyclic imides, Dehydration, antibacterial , antifungal activities

Abstract

The objective of this study was to design and synthesize novel sulfa drugs by incorporating different cyclic imides into their structures. This goal was achieved in two steps. In the first step, four selected sulfa drugs, including sulfamerazine, sulfamethazine, sulfadiazine, and sulfamethoxazole, were reacted with different cyclic anhydrides, namely (maleic, phthalic, and succinic) anhydrides producing N-Drug amic acids (1-6). In the second step, the dehydration of compounds (1-6) was carried out through a fusion process to produce the target corresponding imides (N-Drug imides) (7-12). The results of the biological activity study indicated that the developed drugs (7-12) show very high antimicrobial.