Synthesis, Identification and Evaluation Antioxidant of Some New Pyrazole and Pyrimidine Derivatives From Metoclopramide Drug

Abstract

Oxidative stress is recognized as a major contributor to the development of serious diseases. Therefore, there is a significant demand in medicinal chemistry for the discovery of new potent antioxidants with high efficiency and low toxicity. In this context, we describe the design, synthesis, molecular modeling, and antioxidant evaluation of novel hybrids containing pyrazole or pyrimidine. The compounds were designed, synthesized, and characterized by FT-IR, ¹H-NMR, ¹³C-NMR, and physical properties. The synthetic process begins by reacting Metoclopramide with sodium nitrite, followed by a coupling reaction with methyl acetoacetate and acetylacetone, respectively, to form stable and colored compounds [S1, S2] in an alkaline medium of sodium hydroxide. Subsequently, the Metoclopramide derivative [S1] is treated with hydrazine hydrate and its derivatives to produce pyrazole compounds [S3-S8]. Finally, compound [S2] reacted with urea or thiourea to give pyrimidine compounds [S9, S10].