Study of Adsorption and Release Kinetics of Ciprofloxacin Drug on Prepared γ-Mesoporous Alumina

Abstract

This study focuses on the adsorption and release kinetics of the antibiotic ciprofloxacin (CIP) using previously synthesized γ- Mesoporous Alumina (γ-MA). The experiments of the adsorption kinetic study were carried out by batch method for 240 min, while release kinetics study were carried out via a dialysis bag method maintained at 37 °C with continuous magnetic stirring. The adsorption kinetics analysis was performed using three kinetics models: pseudo 1^st order, pseudo 2^nd order and intraparticle diffusion. Results indicating that the CIP  adsorption is pseudo-2^nd order reaction according to the values of correlation coefficient (R²) for the linear graphs. The intraparticle diffusion model revealed a two-step adsorption mechanism: the first linear section is responsible to the CIP molecules' diffusion between particles and the second linear section is the diffusion that occurs within tiny pores. Also, the release kinetics analysis performed using three kinetics models the Korsmeyer – Peppas, 1st order, and Kopcha, and the findings indicate that the Korsmeyer-Peppas model provided the most accurate fit to the data on releasing kinetics, and values of n suggest that non-Fickian and Fickian diffusion governs the kinetics of CIP release from γ-MA in pH 7 and pH 5 media respectively. Drug loading investigation showed CIP loaded of 2.82 mg per gram of γ-MA. The release profile for CIP loaded on γ-MA     (CIP/γ-MA) system shows that the drug release percentage after 1560 min (26 hours) was about 51.47 % in pH 7 media, and about 35.29 % in pH 5 media.