Synthesis of new cyclic imides bearing drug or heterocycles, depending on Mannich and Gabriel Reactions, with study of their antimicrobial activity

Abstract

This study describes the synthesis of two novel cyclic imide derivatives incorporating drug components or heterocyclic moieties. The first series (compounds 6-13) features a cyclic imide connected to a hetero ring through methylene group, synthesized via the Mannich reaction using N-unsubstituted cyclic imide with heterocyclic amine and formaldehyde. The second series (compounds 15-18) involve cyclic imide fused with the drug molecule (sulfamethoxazole) through acetamido group, achieved via the Gabriel reaction by reacting the potassium salt of N-unsubstituted imide with chloro acetamido sulfamethoxazole. The antimicrobial activity of the newly synthesized imides was evaluated, yielding promising results. The synthesized compounds have been characterized by FTIR, ¹HNMR and ¹³CNMR.